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Abbreviations APAP : Acetaminophen GJ : Gap-junction NAC : N-acetylcysteine GSH : Glutathione NAPQI : N-acetyl-p-benzoquinone imine ROS : Reactive oxygen species Nrf2 : Nuclear factor E2-related factor 2 Cx32 : Connexin 32 TTSP : Type II transmembrane serine protease HGF : Hepatocyte growth factor References Chiew AL, Isbister GK

Patients with a history of Pancreatitis and Thyroid cancer should avoid taking it due to its adverse effects

Summary: Retatrutide can alter bowel habits, with both diarrhoea and constipation reported in Phase 2 clinical trials, consistent with the class effects of GLP-1 receptor agonists

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